James Raftery, professor of health technology assessment at the University of Southampton (UK) has reviewed NICE guidance issued between 1999 and 2005, in an article in the BMJ.
"Overall NICE must be judged to have succeeded in surviving some controversial decisions. Its appeal system has imposed consistency and has so far prevented appellants proceeding to legal challenge. Although clinicians have understandably feared blanket restrictions, these have been fairly rare. NICE continues to be best characterised not by saying no, but by saying yes but... "
Read the paper in the BMJ, 2006;332:1266-1268 (27 May)