Silencing Genomes is to do with RNAi. The discovery of RNAi won the Nobel Prize for Physiology or Medicine in 2006.
I quote from the Silencing Genomes site:
"RNAi is a mechanism that down-regulates gene expression when double-stranded RNA (ds-RNA) molecules that correspond to a part of a "target gene" are present in a cell. By deliberately introducing defined sequences of dsRNA into living organisms, biologists can observe the physiological consequences of "silencing" virtually any gene in C. elegans, as well as other plants and animals."
There are parts of the site dealing with culturing E. coli, C. elegans, observing wild type and mutant C. elegans, and with RNAi.