Issue 37 of the DFID magazine Developments
has an article about Professor John Crofton
, who is now 95, and has been working in tuberculosis research and treatment for 70 years. He devised the "Edinburgh Method", the combination of three drugs that was the standard treatment. The use of that regimen apparently led to TB being virtually wiped out in Edinburgh within 6 years.
Failure to comply with the course of treatment led to the development of multidrug resistant TB, which in turn has led to the development of extreme drug-resistant TB (XDR-TB).